<i>Paecilomyces cicadae</i>: a systematic overview of the biological activities and potential mechanisms of its active metabolites

The microbe Paecilomyces cicadae (Miquel) Samson (P. cicadae) is an asexual strain of Cordyceps (C. used in traditional Chinese medicine. Due to the abundance secondary metabolites found cultured metabolites, including polysaccharides, hyaluronic acid, ergosterol peroxide, and active nucleosides, P. and/or C. exhibit several therapeutic activities, immunoregulatory, antioxidant, anti-diabetic effects. Given great attention for health care desirable medical value cicadae, they are becoming potential alternatives sinensis sinensis). Although there many studies on cicadae/C. most them experimental research articles. There limited reviews summarize latest researches cicadae. This review mainly focuses physiological activities mechanisms action can serve as a theoretical basis more efficient use this medicinal fungus.